Table 1.

NHS England mainstream testing criteria since April 2022 for breast cancer for R208

Living affected individual (proband) with breast or ovarian cancer where the individual +/− family history meets 1 of the criteria. The proband has the following:

a.Breast cancer (age < 40 years, excluding grade 1 breast cancers), OR

b.Bilateral breast cancer (age < 50 years), OR

c.Triple-negative breast cancer (age < 60 years), OR

d.Male breast cancer (any age), OR

e.Breast cancer (age <45 years) and a first-degree relative with breast cancer (age <45 years), OR

f.Pathology-adjusted Manchester score ≥15 or CanRisk score ≥10%

g.Ashkenazi Jewish ancestry and breast cancer at any age