Table 2.
Population based testing of breast cancer by age and family history
| Age (yrs) | Number | % All BC | BRCA1 | BRCA2 | BRCA1/BRCA2 | % | PALB2 | Any PV | % Any PV |
|---|---|---|---|---|---|---|---|---|---|
| <40 | 70 | 6.6% | 5 | 2 | 7 | 10.0% | 2 | 9 | 12.9% |
| FH+ | 11 | 2 | 1 | 3 | 27.3% | 0 | 3 | 27.3% | |
| FH- | 59 | 3 | 1 | 4 | 6.8% | 2 | 6 | 10.2% | |
| 40-49 | 186 | 17.5% | 3 | 7 | 10 | 5.4% | 3 | 13 | 6.9% |
| FH+ | 43 | 2 | 1 | 3 | 7.0% | 0 | 3 | 7.0% | |
| FH- | 143 | 1 | 6 | 7 | 4.9% | 3 | 10 | 7.0% | |
| 50-59 | 396 | 37.6% | 1 | 7 | 8 | 2.0% | 4 | 12 | 3.0% |
| FH+ | 90 | 0 | 4 | 4 | 4.4% | 3 | 7 | 7.8% | |
| FH- | 306 | 1 | 3 | 4 | 1.3% | 1 | 5 | 1.6% | |
| 60-69 | 315 | 29.8% | 0 | 2 | 2 | 0.6% | 0 | 2 | 0.6% |
| FH+ | 67 | 0 | 1 | 1 | 1.5% | 0 | 1 | 1.5% | |
| FH- | 248 | 0 | 1 | 1 | 0.40% | 0 | 1 | 0.4% | |
| 70+ | 96 | 9.0% | 0 | 0 | 0 | 0.00% | 0 | 0 | 0.0% |
| FH+ | 28 | ||||||||
| FH- | 66 | ||||||||
| Total FH+ | 239 | 22.5% | 4 | 7 | 11 | 4.6% | 3 | 14 | 5.8% |
| Total FH+ | 822 | 77.5% | 5 | 11 | 16 | 1.9% | 6 | 22 | 2.7% |
| Mean age | 56.74 | ||||||||
| Median age | 56.89 | ||||||||
| IQR | 50.48-64.43 |
BC, breast cancer; FH+, first degree family history of BC; PV, pathogenic variant.