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. 2024 Dec 3;19(12):e0312379. doi: 10.1371/journal.pone.0312379

Table 2. Active ZJP components interacted with ZJP anti-myopic targets.

MOL ID compound name Protein name Gene name count
MOL000098 quercetin 30
Stromelysin-1 MMP3
Epidermal growth factor receptor EGFR
RAC-alpha serine/threonine-protein kinase AKT1
Vascular endothelial growth factor A VEGFA
Proto-oncogene c-Fos FOS
72 kDa type IV collagenase MMP2
Matrix metalloproteinase-9 MMP9
Interleukin-10 IL10
Pro-epidermal growth factor EGF
Tumor necrosis factor TNF
Interleukin-6 IL6
Cellular tumor antigen p53 TP53
RAF proto-oncogene serine/threonine-protein kinase RAF1
Superoxide dismutase [Cu-Zn] SOD1
Interstitial collagenase MMP1
Hypoxia-inducible factor 1-alpha HIF1A
Gap junction alpha-1 protein GJA1
Interleukin-8 CXCL8
Transforming growth factor beta-1 TGFB1
Cytochrome P450 1B1 CYP1B1
Collagen alpha-1(I) chain COL1A1
Arachidonate 5-lipoxygenase PTEN
Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN PTEN
Neutrophil cytosol factor 1 NCF1
Aryl hydrocarbon receptor AHR
Collagen alpha-1(III) chain COL3A1
Runt-related transcription factor 2 RUNX2
Insulin-like growth factor-binding protein 3 IGFBP3
Insulin-like growth factor II IGF2
Receptor tyrosine-protein kinase erbB-3 ERBB3
MOL000006 luteolin 13
Epidermal growth factor receptor EGFR
RAC-alpha serine/threonine-protein kinase AKT1
Vascular endothelial growth factor A VEGFA
72 kDa type IV collagenase MMP2
Matrix metalloproteinase-9 MMP9
Interleukin-10 IL10
Tumor necrosis factor TNF
Interleukin-6 IL6
Cellular tumor antigen p53 TP53
Interstitial collagenase MMP1
Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1
Tyrosinase TYR
Hepatocyte growth factor receptor MET
MOL002773 beta-carotene 7
RAC-alpha serine/threonine-protein kinase AKT1
Vascular endothelial growth factor A VEGFA
72 kDa type IV collagenase MMP2
Interstitial collagenase MMP1
Catenin beta-1 CTNNB1
Gap junction alpha-1 protein GJA1
Stromelysin-2 MMP10
MOL000422 kaempferol 7
Nitric oxide synthase, inducible NOS2
Muscarinic acetylcholine receptor M1 CHRM1
RAC-alpha serine/threonine-protein kinase AKT1
Tumor necrosis factor TNF
Interstitial collagenase MMP1
Cytochrome P450 1B1 CYP1B1
Aryl hydrocarbon receptor AHR
MOL000546 diosgenin 6
RAC-alpha serine/threonine-protein kinase AKT1
Vascular endothelial growth factor A VEGFA
Cellular tumor antigen p53 TP53
Superoxide dismutase [Cu-Zn] SOD1
Hypoxia-inducible factor 1-alpha HIF1A
Serine/threonine-protein kinase mTOR MTOR
MOL000354 isorhamnetin 4
Nitric oxide synthase, inducible NOS2
Estrogen receptor ESR1
Glycogen phosphorylase, muscle form PYGM
Neutrophil cytosol factor 1 NCF1
MOL001558 sesamin 3
Interleukin-10 IL10
Peroxisomal acyl-coenzyme A oxidase 1 ACOX1
Trifunctional enzyme subunit beta, mitochondrial HADHB
MOL005944 matrine 3
72 kDa type IV collagenase MMP2
Tumor necrosis factor TNF
Interleukin-6 IL6
MOL000787 Fumarine 3
Muscarinic acetylcholine receptor M3 CHRM3
Muscarinic acetylcholine receptor M1 CHRM1
Vascular endothelial growth factor receptor 2 KDR
MOL000358 beta-sitosterol 2
Muscarinic acetylcholine receptor M3 CHRM3
Muscarinic acetylcholine receptor M1 CHRM1
MOL005406 atropine 2
Muscarinic acetylcholine receptor M3 CHRM3
Muscarinic acetylcholine receptor M1 CHRM1
MOL008400 glycitein 2
Estrogen receptor ESR1
Nitric oxide synthase, inducible NOS2
MOL009650 Atropine 2
Muscarinic acetylcholine receptor M3 CHRM3
Muscarinic acetylcholine receptor M1 CHRM1
MOL001243 3alpha-Hydroxy-olean-12-en-24-oic-acid 2
Muscarinic acetylcholine receptor M3 CHRM3
Muscarinic acetylcholine receptor M1 CHRM1
MOL001297 trans-gondoic acid 1
Muscarinic acetylcholine receptor M1 CHRM1
MOL004624 Longikaurin A 1
Muscarinic acetylcholine receptor M1 CHRM1
MOL008978 Gomisin R 1
Estrogen receptor ESR1
MOL001215 tirucallol 1
Muscarinic acetylcholine receptor M3 CHRM3