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. 2024 Nov 20;15:1496043. doi: 10.3389/fphar.2024.1496043

TABLE 4.

Initial dosage recommendations of quetiapine for schizophrenic patients.

Without fluvoxamine With fluvoxamine
Without duloxetine Without duloxetine
Body weight (kg) Dosage (mg/kg/day) Probability to achieve the target concentrations (%) Probability to exceed the upper limit of the target concentrations (%) Body weight (kg) Dosage (mg/kg/day) Probability to achieve the target concentrations (%) Probability to exceed the upper limit of the target concentrations (%)
[40–50) 16 94.0–94.7 3.1–4.6 [40–120] 8 99.3–99.8 0–0.7
[50–120] 12 94.0–97.3 0.2–1.8
With duloxetine With duloxetine
Body weight (kg) Dosage (mg/kg/day) Probability to achieve the target concentrations (%) Probability to exceed the upper limit of the target concentrations (%) Body weight (kg) Dosage (mg/kg/day) Probability to achieve the target concentrations (%) Probability to exceed the upper limit of the target concentrations (%)
[40–120] 8 99.3–99.8 0–0.7 [40–120] 4 99.9–100.0 0