Table 2.
A simplified overview of scales for QoL assessment.
| Scale | Strengths | Limitations |
|---|---|---|
| Parkinson’s Disease Questionnaire-39 (PDQ-39) (24, 31) | Assesses difficulties across 8 dimensions of daily living. Telephone interview versions available for remote assessments Good internal consistency |
Does not provide a comprehensive overview of certain clinical features of PSP. |
| Progressive Supranuclear Palsy Quality of Life Scale (PSP-QoL) (25) | Assess items of high clinical significance and importance from the patient’s point of view (19) Highly reliable with good face and construct validity |
Responsiveness of the PSP-QoL not tested. |
| EuroQol instrument (EQ-5D) (26, 27) | Improved sensitivity and reduced ceiling effects. Available in numerous languages and in various modes of administration. |
Insensitive to some specific PSP features (19) |
| Parkinson’s Disease Questionnaire (PDQ-8) (31) | Short-form version, derived from PDQ-39 | Non-motor impairment (oculomotor, mental) less evaluated (36) |
| Modified Progressive Supranuclear Palsy Rating Scale (mPSPRS) (37) | Reflects a wide range of functional disabilities in PSP patients. Good sensitivity to change. |
Preferred in clinical trials |
| Progressive Supranuclear Palsy Clinical Deficits Scale (PSP-CDS) (38) | Uncomplicated formula feasible in clinical practice | - |
| Sickness Impact Profile (SIP) (44) | Widely covers different functional areas. | Formula requiring longer evaluation time, which may affect its use in clinical settings, particularly among patients with advanced deterioration. |
| Medical Outcome Study 36-Item Short Form Health Survey (SF-36) (45) | Widely used, well-researched – comparable results from different diseases studied | Largely limited by floor and ceiling effects. |
| Life Satisfaction Questionnaire (LSQ) (43) | Requires a short completion time in clinical settings. | Not designed for motor disorders Very general findings |
| Nottingham Health Profile (NHP) (57–59) | Requires a short completion time in clinical settings. | Not designed for motor disorders Very general findings |
| Quality of Well-Being Scale (QWBS) (65) | Assesses last 3 days of QoL experience. | Not designed for motor disorders Very general findings |
| Quality-of-Life Questionnaire 15D (15D) (66) | Requires a short completion time in clinical settings. | Not designed for motor disorders Very general findings |
PSP, progressive supranuclear palsy; QoL quality of life.