Fig. 1. Schematic illustration of our heat-guided drug delivery system (DDS).

Upon external heating above the LCST, the pair of thermo-responsive micelles, DBCO-TRM and Az-TRM, are trapped at the heated site due to their increased size via hydrophobic aggregation between their dehydrated thermo-responsive shells. Further, irreversible crosslinking between DBCO-TRM and Az-TRM is induced by azide-alkyne click chemistry in response to the thermally exposure of the azide moieties on Az-TRM surface, leading to efficient delivery of the micelles after cessation of heating.