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. 2024 Sep 16;27(10):110980. doi: 10.1016/j.isci.2024.110980

Experimental groups and procedure of the study

Experimental Groups Experimental Procedure
1) CONTROL Vehicle solution (saline) was injected intraperitoneally for 7 consecutive days 10
2) CONTROL +PF-475 2.5 mg/kg PF-475 2.5 mg/kg was administered intraperitoneally for 7 consecutive days starting 24 h after vehicle solution injection 10
3) CONTROL + PF-475 5 mg/kg PF-475 5 mg/kg was administered intraperitoneally for 7 consecutive days starting 24 h after vehicle solution injection 10
4) CONTROL + PF-475 10 mg/kg PF-475 10 mg/kg was administered intraperitoneally for 7 consecutive days starting 24 h after vehicle solution injection 10
5) MPTP MPTP solution was administered intraperitoneally during the first day, and saline intraperitoneal administration for 7 consecutive days starting 24 h after MPTP injection. 10
6) MPTP + PF-475 2.5 mg/kg MPTP solution was administered intraperitoneally during the first day, and PF-475 2.5 mg/kg intraperitoneal administration for 7 consecutive days starting 24 h after MPTP injection. 10
7) MPTP + PF-475 5 mg/kg MPTP solution was administered intraperitoneally during the first day, and PF-475 5 mg/kg intraperitoneal administration for 7 consecutive days starting 24 h after MPTP injection. 10
8) MPTP + PF-475 10 mg/kg MPTP solution was administered intraperitoneally during the first day, and PF-475 10 mg/kg intraperitoneal administration for 7 consecutive days starting 24 h after MPTP injection. 10