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. 2024 Dec 4;15:10547. doi: 10.1038/s41467-024-55043-x

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — A H&E staining of representative pancreas and liver tissue from (n = 4) control or CVB3 infected p48^cre;LSL-Kras^G12D mice. Tissue was collected at week 38 after infection. The bar indicates 200 µm. B Kaplan–Meier curve showing significantly reduced survival in n = 7 CVB3-infected p48^cre;LSL-Kras^G12D mice (red line) as compared to n = 7 PBS control p48^cre;LSL-Kras^G12D (black line, p = 0.0471; Log-rank (Mantel–Cox) test. The median survival of KC + vehicle is 87 weeks, and the median survival of KC + CVB3 is 38 weeks. Sex of animals is indicated by the symbols. Source data are provided as a Source Data file. C Model of how CAR in oncogenic KRas expressing lesions facilitates CVB3 infection, and how this can contribute to the progression to high-grade PanIN and PDA.