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. 2024 Dec 3;14:29586. doi: 10.1038/s41598-024-80252-1

Fig. 3.

Fig. 3

Effect of the environmental temperature near mouse embryos at the early stage on the Igf1 and Igfbp2 expressions in the hypothalamus and liver and the Igfbp5, Igf1r and insr in the hypothalamus of the grown-up male mice. (a) Expression level of Igf1 mRNA in the hypothalamus (n = 10 in each of the 37 °C and 38 °C groups) and liver (n = 8 in each group). Error bar shows SEM. * p-value < 0.05 (Student’s t-test). (b) Expression level of Igfbp2 mRNA in the hypothalamus (n = 11 in each of the 37 °C and 38 °C groups) and liver (n = 8 in each group). Error bar shows SEM. * p-value < 0.05 (Student’s t-test). (c) Expression level of Igfbp5 mRNA in the hypothalamus (n = 11 in each of the 37 °C and 38 °C groups). Error bar shows SEM. (d) Expression level of Igf1r mRNA in the hypothalamus (n = 10 in each of the 37 °C and 38 °C groups). Error bar shows SEM. (e) Expression level of Insr mRNA in the hypothalamus (n = 10 in each of the 37 °C and 38 °C groups). Error bar shows SEM.