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. 2024 Dec 3;14:29586. doi: 10.1038/s41598-024-80252-1

Fig. 5.

Fig. 5

Effect of cKO of brain Igfbp2 on Tc of adult mice exposed to the environmental temperature of 38 °C at their early stage of embryos. (a, b) Circadian rhythms of Tc (a) and activity (b) of the male Igfbp2 cKO and the control mice (n = 4 in each group) exposed to 38 °C at their early stage of embryo. Error bar shows SEM. (c) AUC of the temperature changes from ZT3 to ZT12 and ZT19 to ZT23. Error bar shows SEM. * p-value < 0.05 (Student’s t-test). ** p-value < 0.01 (Student’s t-test). (d) Total activity (counts) from ZT3 to ZT12 and ZT19 to ZT23. Error bar shows SEM. (e) Body weight of 8-weeks old Igfbp2 cKO mice exposed to the environmental temperature of 38 °C at their early stage of the embryo. Igfbp2 cKO and the control mice (n = 4 in each group) were used. Error bar shows SEM.