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. 2024 Dec 3;14:30098. doi: 10.1038/s41598-024-80646-1

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Fig. 2 — Significant gene silencing efficiency using SWNT-siRNA conjugates. (A) Graphical representation of SWNT-PL-PEG-S-S-siRNA. (B) Graphical representation of SWNT-PL-PEG-siRNA. (C, D and E) Evaluation of gene silencing effect by SWNT-PL-PEG-S-S-siGFP and SWNT-PL-PEG-siGFP conjugates in MCF-7, HEK-293T, H1299 and HeLa cells. Cells expressing stable green fluorescent protein (GFP) were treated with SWNT-PL-PEG-S-S-siGFP or SWNT-PL-PEG-siGFP conjugates at a concentration of 100 nM siGFP. The cell nuclei were stained with DAPI (blue). Microscopic observation was captured under 100x magnification. Bars represent mean ± SD of at least 3 independent experiments. * represents statistical significance as compared to vehicle controls (Student’s t-test, p < 0.01).