Figure 3.

Timeline: retrospective analysis of histatin-dependent effects in tissue repair

The timeline shows the main findings related to the roles histatins in cell and tissue repair. These include the effects at the cellular level, namely cell adhesion, spreading, and migration. Also, the effects of histatins in soft and mineralized tissue repair are shown, along with the different therapeutic strategies that have been proposed in animal models. The impact of histatins on angiogenesis and the consequences in tissue repair are highlighted.