Fig. 2.

White matter pathology relates to free water and blood–brain barrier disruption. White matter was segmented into white matter hyperintensities (WMH), a WMH penumbra after dilating by 3 mm, and normal appearing white matter (NAWM). A) Mean free water (FW) was different across each white matter region. B) Mean blood-brain barrier disruption (BBBD) was elevated in WMH relative to penumbra or NAWM. There was no difference between mean BBBD in NAWM and penumbra. *Indicates pairwise comparison with p < 0.001.