Table 2.

Associations between demographic, etiological, and lifestyle factors and risk of incident HCC among patients with cirrhosis.

		Crude HR (95% CI)	P-value	Adjusted HR** (95% CI)	P-value
Age, years
	<55	1.00 (ref)		1.00 (ref)
	55–<65	1.86 (1.07–3.21)	0.0266	1.87 (1.03–3.41)	0.0397
	≥65	2.08 (1.19–3.62)	0.0097	2.26 (1.25–4.08)	0.0072
Sex
	Female	1.00 (ref)		1.00 (ref)
	Male	1.57 (1.04–2.37)	0.0334	1.58 (1.03–2.44)	0.0364
Race/ethnicity
	NH-White	1.00 (ref)		1.00 (ref)
	NH-Black	0.57 (0.33–1.00)	0.0512	0.47 (0.26–0.85)	0.0118
	Hispanic	0.81 (0.53–1.24)	0.3355	0.85 (0.55–1.32)	0.4746
	Others	0.56 (0.14–2.29)	0.4230	0.68 (0.17–2.74)	0.5831
HCV status*
	No	1.00 (ref)		1.00 (ref)
	Yes	1.49 (1.04–2.15)	0.0314	1.66 (1.13–2.44)	0.0102
PNPLA3 G risk allele carrier status
	Noncarrier	1.00 (ref)		1.00 (ref)
	Carrier	1.51 (1.02–2.22)	0.0379	1.62 (1.08–2.45)	0.0210
Current heavy alcohol consumption
	No	1.00 (ref)		1.00 (ref)
	Yes	1.41 (0.73–2.72)	0.3058	1.43 (0.75–2.75)	0.2774
Obesity
	No	1.00 (ref)		1.00 (ref)
	Yes	1.32 (0.91–1.90)	0.1444	1.37 (0.94–2.00)	0.0976

^*Active or cured HCV infection.

^**Full model included all terms in the table.