Table 3.

Joint association of PNPLA3 I148M variant, current heavy alcohol consumption, and obesity with risk of incident HCC among patients with cirrhosis.

	Unadjusted HR (95% CI)	P-value	Adjusted HR (95% CI)	P-value
Alcohol use & PNPLA3 genotype*
No current heavy, noncarrier	1.00 (ref)		1.00 (ref)
No current heavy, carrier	1.42 (0.95–2.13)	0.0848	1.54 (1.01–2.35)	0.0467
Current heavy, noncarrier	0.77 (0.18–3.21)	0.7180	0.86 (0.21–3.54)	0.8367
Current heavy, carrier	2.58 (1.18–5.63)	0.0172	2.65 (1.20–5.86)	0.0158
BMI & PNPLA3 genotype**
Non-obese, noncarrier	1.00 (ref)		1.00 (ref)
Non-obese, carrier	1.70 (0.94–3.05)	0.0775	1.83 (1.01–3.35)	0.0482
Obese, noncarrier	1.45 (0.76–2.77)	0.2580	1.51 (0.79–2.90)	0.2117
Obese, carrier	2.01 (1.15–3.49)	0.0139	2.40 (1.33–4.31)	0.0035
Alcohol use & BMI***
Non-obese, no current heavy	1.00 (ref)		1.00 (ref)
Non-obese, current heavy	1.61 (0.67–3.84)	0.2841	1.50 (0.63–3.55)	0.3569
Obese, no current heavy	1.36 (0.92–2.00)	0.1209	1.38 (0.93–2.05)	0.1066
Obese, current heavy	1.82 (0.65–5.09)	0.2566	1.88 (0.68–5.19)	0.2247

^*Adjusted for age, gender, race/ethnicity, HCV, and BMI (obesity)

^**Adjusted for age, gender, race/ethnicity, HCV, and alcohol consumption

^***Adjusted for age, gender, race/ethnicity, HCV, and PNPLA3 gene