Table 1.

Demographical and clinical description of the full sample

	Pooled estimate (mean/frequency)	95%CI	Npatients	Nsites	I2
Demographics
Sex (% women)	60%	[56, 64]	1092	36	35.0
Handedness (% right)	93%	[90, 95]	872	32	42.8
Years of education	14.1	[13.9, 14.2]	949	35	93.1
APOE (% e4 carriers)	43%	[35, 50]	451	22	55.5
Clinical
Age at symptom onset, years	59.4	[58.9, 59.8]	1031	34	77.4
Age at diagnosis, years	63.2	[62.8, 63.6]	1067	36	76.8
Age at death, years	70.5	[69.5, 71.4]	227	20	72.7
Diagnosis (% PCA pure)	80%	[72, 89]	968	34	97.9
MMSE at diagnosis, points (range : 0–30)	20.7	[20.4, 21.1]	904	31	69.9
CDR at diagnosis (% CDR≥1)	62%	[53, 71]	558	27	81.1
Mendez criteria (% fulfilled)	75%	[60, 90]	535	21	99.4
Tang-Wai criteria (% fulfilled)	80%	[68, 92]	535	21	98.6
Early disturbance of posterior function (% yes)	91%	[85, 97]	992	36	98.1
Insidious onset and gradual progression (% yes)	99%	[98, 99]	809	34	0

Mean values or frequency, and their corresponding 95% confidence intervals are derived from the meta-analysis of all available data. Sites with only one available datapoint (two sites for “MMSE”, one site for “age at death”) were not included in the meta-analysis. Raw data, including breakdown of each site, is presented in Supplementary Figures 1–10. Abbreviations: MMSE: Mini-Mental State Examination, CDR: Clinical Dementia Rating scale.