Table 3.
Primary neuropathological diagnosis | Age at symptom onset | Age at death | Diagnosis | sex | APOE4 status | Thal phase | NFT Braak stage | CERAD score | ADNC level | Site |
---|---|---|---|---|---|---|---|---|---|---|
| ||||||||||
LBD | 67 | 71 | PCA plus | M | e4 carrier | 5 | IV | moderate | intermediate | S01 |
LBD | 61 | 70 | PCA pure | F | - | - | IV | frequent | intermediate | S03 |
LBD | 58 | 68 | - | M | e4 carrier | 5 | VI | frequent | high | S05 |
LBD | 79 | 87 | - | M | non-carrier | 4 | V | frequent | high | S05 |
FTLD-tau (CBD) | 58 | 64 | PCA plus | M | e4 carrier | 2 | II | sparse | low | S20 |
FTLD-tau (CBD) | 51 | 57 | PCA pure | M | non-carrier | 0 | 0 | none | none | S24 |
Brain infarct | 90 | 91 | - | F | - | 1 | 0 | sparse | low | S26 |
Brain infarct | 88 | 94 | - | F | - | 0 | 0 | none | none | S26 |
FTLD-TDP43 Type A | 59 | 68 | PCA pure | M | - | 0 | 0 | none | none | S24 |
FTLD-tau (Pick’s) | 58 | 68 | PCA pure | F | e4 carrier | 2 | I | moderate | low | S05 |
Abbreviations: LBD: Lewy body disease, FTLD: frontotemporal lobar degeneration, CBD: corticobasal degeneration, TDP-43: TAR DNA-binding protein 43, APOE4: allele ε4 of the apolipoprotein E gene, NFT: Neurofibrillary Tangles, CERAD: Consortium to Establish a Registry for Alzheimer’s Disease, ADNC: Alzheimer’s Disease Neuropathological changes, MMSE: Mini-Mental State Examination; CDR: Clinical Dementia Rating scale. Corresponding site descriptions can be found in Supplementary Table 2.