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. Author manuscript; available in PMC: 2024 Dec 4.
Published in final edited form as: Lancet Neurol. 2024 Feb;23(2):168–177. doi: 10.1016/S1474-4422(23)00414-3

Table 3.

Clinical characteristics of the 10 patients with non-AD primary neuropathological diagnosis

Primary neuropathological diagnosis Age at symptom onset Age at death Diagnosis sex APOE4 status Thal phase NFT Braak stage CERAD score ADNC level Site

LBD 67 71 PCA plus M e4 carrier 5 IV moderate intermediate S01
LBD 61 70 PCA pure F - - IV frequent intermediate S03
LBD 58 68 - M e4 carrier 5 VI frequent high S05
LBD 79 87 - M non-carrier 4 V frequent high S05
FTLD-tau (CBD) 58 64 PCA plus M e4 carrier 2 II sparse low S20
FTLD-tau (CBD) 51 57 PCA pure M non-carrier 0 0 none none S24
Brain infarct 90 91 - F - 1 0 sparse low S26
Brain infarct 88 94 - F - 0 0 none none S26
FTLD-TDP43 Type A 59 68 PCA pure M - 0 0 none none S24
FTLD-tau (Pick’s) 58 68 PCA pure F e4 carrier 2 I moderate low S05

Abbreviations: LBD: Lewy body disease, FTLD: frontotemporal lobar degeneration, CBD: corticobasal degeneration, TDP-43: TAR DNA-binding protein 43, APOE4: allele ε4 of the apolipoprotein E gene, NFT: Neurofibrillary Tangles, CERAD: Consortium to Establish a Registry for Alzheimer’s Disease, ADNC: Alzheimer’s Disease Neuropathological changes, MMSE: Mini-Mental State Examination; CDR: Clinical Dementia Rating scale. Corresponding site descriptions can be found in Supplementary Table 2.