Table 4.

MR analysis on association between OPG and follow-up PWV.

Instrumental variable	Effect allele	Other allele	Effect allele frequency	Coefficient of OPG per allele (SE)	p-value	Coefficient (95%CI) for follow-up PWV per allele	p-value	MR estimate of follow-up PWV per unit increase in OPG (95% CI)	p-value
rs1385492	G	A	0.413	0.07 (0.033)	0.029	0.78 (0.21 to 1.35)	0.007	10.81 (2.97 to 18.65)	0.007

OPG, osteoprotegerin; PWV, pulse wave velocity; SE, standard error; CI, confidence interval.

Adjusted for age, sex, population structure and baseline PWV.