Skip to main content
. 2024 Dec 4;10(49):eadl0649. doi: 10.1126/sciadv.adl0649

Fig. 5. AlFoM model of the heterodimer of EGFR residues 669 to 1210 (cyan) and EphA2 residues 559 to 976 (purple).

Fig. 5.

Predictions are shown for EphA2 WT (A) or for the S897E/S901E mutant (B) representative of phosphorylation at serine residues (red bubbles). Yellow residues indicate the active site of each kinase region. The purple halo encompasses the EphA2 SAM domain, while the cyan halo shows the EGFR JM domain. The red arrow indicates the EphA2 kinase active site, which is sterically blocked by the EGFR kinase domain in (A), but not in (B).