Table 1.
Baseline characteristics and univariate analysis of the survival of SMPESCs patients.
| Variables | Value, n (%) | Univariate analysis P value |
|
|---|---|---|---|
| DFS | OS | ||
| Age, years | 0.068 | 0.040 | |
| ≤ 67 | 110 (81.5) | ||
| >67 | 25 (18.5) | ||
| Sex | 0.702 | 0.232 | |
| Male | 113 (83.7) | ||
| Female | 22 (16.3) | ||
| BMI (kg/m²) | 0.032 | 0.019 | |
| ≤ 18.5 | 11 (8.1) | ||
| 18.5–22.9 | 86 (63.7) | ||
| ≥ 23.0 | 38 (28.2) | ||
| Smoking and drinking history | 0.960 | 0.904 | |
| No | 47 (34.8) | ||
| Yes | 88 (65.2) | ||
| Preoperative comorbidity | 0.826 | 0.873 | |
| No | 117 (86.7) | ||
| Yes | 18 (13.3) | ||
| Family history | 0.074 | 0.312 | |
| No | 109 (80.7) | ||
| Yes | 26 (19.3) | ||
| Hemoglobin (g/L) | 0.023 | 0.015 | |
| ≤125.5 | 18 (13.3) | ||
| >125.5 | 117 (86.7) | ||
| A/G | 0.041 | 0.280 | |
| ≤1.71 | 103 (76.3) | ||
| >1.71 | 32 (23.7) | ||
| LDH (U/L) | 0.011 | 0.026 | |
| ≤183.7 | 96 (71.1) | ||
| >183.7 | 39 (28.9) | ||
| ALP (U/L) | 0.308 | 0.156 | |
| ≤ 92.0 | 116 (85.9) | ||
| >92.0 | 19 (14.1) | ||
| NLR | 0.225 | 0.557 | |
| ≤ 2.4 | 87 (64.4) | ||
| >2.4 | 48 (35.6) | ||
| PLR | 0.149 | 0.317 | |
| ≤ 144.9 | 94 (69.6) | ||
| >144.9 | 41 (30.4) | ||
| LMR | 0.013 | 0.003 | |
| ≤ 4.00 | 75 (55.6) | ||
| >4.00 | 60 (44.4) | ||
| Surgical procedure | 0.457 | 0.817 | |
| Minimally invasive | 100 (74.1) | ||
| Open | 35 (25.9) | ||
| Operative approach | 0.744 | 0.242 | |
| Right thoracic | 111 (82.2) | ||
| Left thoracic | 24 (17.8) | ||
| Number of lesions | 0.728 | 0.558 | |
| 2 | 121 (89.6) | ||
| ≥ 2 | 14 (10.4) | ||
| Site of main lesion | 0.014 | 0.011 | |
| Upper thoracic portion | 10 (7.4) | ||
| Middle thoracic portion | 47 (34.8) | ||
| Lower thoracic portion | 78 (57.8) | ||
| Length of main lesion (mm) | 0.053 | 0.071 | |
| ≤ 15 | 23 (17.0) | ||
| >15 | 112 (83.0) | ||
| Differentiation of main lesion | 0.860 | 0.541 | |
| High differentiation | 23 (17.0) | ||
| Moderate differentiation | 77 (57.0) | ||
| Poor differentiation | 35 (26.0) | ||
| pT of main lesion | 0.014 | 0.016 | |
| T1 | 27 (20.0) | ||
| T2 | 24 (17.8) | ||
| T3 | 84 (62.2) | ||
| Site of second lesion | 0.140 | 0.213 | |
| Upper thoracic portion | 48 (35.6) | ||
| Middle thoracic portion | 44 (32.6) | ||
| Lower thoracic portion | 43 (31.8) | ||
| Differentiation of second lesion | 0.089 | 0.064 | |
| High differentiation | 64 (47.4) | ||
| Moderate differentiation | 45 (33.3) | ||
| Poor differentiation | 26 (19.3) | ||
| pT of second lesion | 0.016 | 0.019 | |
| Tis/T1 | 101 (74.8) | ||
| T2 | 24 (17.8) | ||
| T3 | 10 (7.4) | ||
| Lymph node metastasis | <0.001 | <0.001 | |
| Yes | 82 (60.7) | ||
| No | 53 (39.3) | ||
| TNLD | 0.015 | 0.093 | |
| ≤ 25 | 61 (45.2) | ||
| >25 | 74 (54.8) | ||
| Postoperative adjuvant therapy | 0.925 | 0.388 | |
| No | 91 (67.4) | ||
| Yes | 44 (32.6) | ||
| Extent of lymph node dissection | 0.070 | 0.116 | |
| Two fields | 117 (86.7) | ||
| Three fields | 18 (13.3) | ||
A/G: albumin/globulin ratio; ALP: alkaline phosphatase; BMI: body mass index; DFS: disease-free survival; LDH: lactate dehydrogenase; LMR: lymphocyte-to-monocyte ratio; NLR: neutrophil-to-lymphocyte ratio; OS: overall survival; PLR: platelet-to-lymphocyte ratio; SMPESCs: synchronous multiple primary esophageal squamous carcinomas; TNLD: total number of lymph nodes dissected.