Table 1. Unstandardized coefficients (β) and 95% confidence intervals (CI) from gamma GLMM of gestational length (in days) over three time points in pregnancy (with ethnicity as a random effect). Early, mid- and late pregnancy GLMMs using Lactobacillus status (dominated/depleted), as well as an early CST GLMM, which replaces the Lactobacillus covariate with CST. Secretors with Lactobacillus-dominated microbiota (or CST 1) are baseline in the model.
Early | Mid | Late | Early (CST) | |
β (95% CI) | β (95% CI) | β (95% CI) | β (95% CI) | |
Intercept | 3.375 (2.609, 4.142)‡ | 3.053 (2.302, 3.804)‡ | 2.894 (2.140, 3.649)‡ | 3.263 (2.462, 4.064)‡ |
Maternal age | 0.003 (−0.013, 0.019) | 0.010 (−0.006, 0.026) | 0.013 (−0.003, 0.029) | 0.006 (−0.011, 0.022) |
BMI | −0.013 (−0.031, 0.006) | −0.007 (−0.024, 0.010) | −0.006 (−0.023, 0.012) | −0.012 (−0.030, 0.007) |
Previous PTB§/MTL¶ | 0.541 (0.353, 0.729)‡ | 0.339 (0.154, 0.524)‡ | 0.324 (0.141, 0.506)‡ | 0.527 (0.330, 0.724)‡ |
Cervical stitch | 0.361 (0.171, 0.552)‡ | 0.414 (0.248, 0.580)‡ | 0.224 (0.056, 0.392)† | 0.366 (0.175, 0.557)‡ |
Previous cervical excisional treatment | −0.138 (−0.330, 0.054) | −0.199 (−0.387, –0.011)* | −0.129 (−0.317, 0.059) | −0.152 (−0.348, 0.044) |
Secretor ×Lactobacillus | 0.617 (0.143, 1.092)* | 0.268 (−0.201, 0.737) | 0.078 (−0.378, 0.534) | |
Secretor ×CST 2 | na(low sample size) | |||
Secretor×CST 3 | 0.264 (−0.172, 0.699) | |||
Secretor×CST 4 | 0.467 (−0.125, 1.060) | |||
Secretor×CST 5 | −0.348 (−1.149, 0.454) |
*P<0.05.
†P<0.01.
‡P<0.001.
§Preterm birth.
¶Mid-trimester loss.