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. Author manuscript; available in PMC: 2024 Dec 4.
Published in final edited form as: Adv Drug Deliv Rev. 2023 Sep 9;202:115083. doi: 10.1016/j.addr.2023.115083

Figure 5.

Figure 5.

Hydrogel drug release kinetics and the influence of hydrogels on tumor and plasma pharmacokinetics. A) Representation of sustained and rapid drug release kinetic profiles for drug-loaded hydrogels measured using an in vitro drug elution assay. B) Sustained drug release from hydrogels can achieve more prolonged exposure of the injected tumor to therapeutic drug concentrations, compared to free drug administered by intratumoral (i.t.) or intravenous (i.v.) injection. C) Sustained drug release from hydrogels reduces peak plasma concentrations and associated systemic toxicity compared to free drug following i.t. or i.v. administration.