Fig 1. World population coverage of Class I and Class II combined, as predicted by the IEDB tool, is depicted in bar chart.

The chart shows the number of epitope and allele combinations (x-axis) recognized by different regions of the world population. Here approximately 5.75% can be recognized by 26 and 29 combinations. The right-hand y-axis shows the cumulative percent of world population coverage. Cumulatively, adding from right to left, it is expected that at least 18 epitopes can be recognized in 90% of individuals. Similarly, slightly over 80% of the world population would recognize 21 and more, while 60% would recognize 26 and more. The coverage value for the whole group of Class I and Class II epitopes is 99.99%.