Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2024 Sep 23;19:248–260. doi: 10.1016/j.aninu.2024.09.002

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2024 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Fig. 4 — Effects of glycyrrhetinic acid (GA) on intestinal pyroptosis-related genes expression induced by high fat diets (HFD). (A) The mRNA expression of intestinal pyroptosis-related genes including cysteinyl aspartate specific proteinase 1 (caspase-1), interleukin-1β (IL-1β), interleukin-18 (IL-18). (B) Protein levels of total HMGB1 and cytoplasm HMGB1. HMGB1 = high mobility group box1. (C) Related protein levels of intestinal pyroptosis-related genes, including RAGE, NLRP3, ASC, pro-caspase-1, caspase-1, GSDME, GSDME-N. RAGE = receptor for advanced glycation end products; NLRP3 = NOD-like receptor family and pyrin domain contain 3; ASC = apoptosis-associated speck-like protein containing a C-terminal caspase recruitment domain; caspase-1 = cysteinyl aspartate specific proteinase 1; GSDME = gasdermin E; GSDME-N N-terminal domain of GSDME. (D) Immunohistochemistry for caspase-1 observed under a fluorescence microscope (scale bar = 100 μm). (E) Lactate dehydrogenase (LDH) content in the serum. Bars with different letters indicate a significant difference (P < 0.05).