Table 2.
Correlations of altered lipid mediators with clinical parameters and inflammatory markers in patients with alcoholic hepatitis.
| Categories | Variables | PGD2 | PGE2 | LTB4 | LXA4 | LTB4/LXA4 | RvE1 | MaR1 |
|---|---|---|---|---|---|---|---|---|
| Demo-graphics | Age | 0.17 | -0.22 | 0.33* | 0.21 | 0.08 | 0.28 | -0.07 |
| Clinical parameters | Creatinine | 0.27 | -0.11 | 0.05 | -0.10 | 0.16 | 0.24 | -0.23 |
| Total Bilirubin | 0.42** | 0.10 | 0.14 | -0.22 | 0.32* | 0.16 | 0.04 | |
| ALT | 0.08 | -0.25 | 0.06 | -0.20 | 0.11 | -0.01 | -0.36* | |
| AST | 0.25 | -0.19 | 0.05 | -0.13 | -0.10 | 0.06 | -0.16 | |
| INR | -0.17 | -0.37 | 0.10 | 0.18 | 0.09 | 0.07 | -0.26 | |
| MELD | 0.25 | 0.02 | 0.13 | -0.19 | 0.31* | 0.16 | -0.14 | |
| Neutrophils | 0.17 | -0.16 | 0.19 | -0.22 | 0.24 | -0.03 | -0.21 | |
| Platelets | 0.28 | 0.35 | -0.10 | -0.14 | -0.07 | -0.33 | 0.46** | |
| BMI | 0.02 | -0.20 | 0.05 | -0.01 | 0.12 | 0.21 | 0.13 | |
| Inflammation markers | CRP | 0.55* | 0.47 | 0.25 | -0.13 | 0.37 | -0.32 | 0.57 |
| LPS | 0.16 | 0.14 | 0.08 | 0.22 | -0.07 | -0.19 | 0.12 | |
| LBP | 0.13 | 0.14 | -0.06 | -0.43** | 0.16 | -0.33 | -0.04 | |
| sCD14 | 0.06 | -0.11 | 0.04 | -0.50** | 0.28 | 0.29 | 0.28 | |
| sCD163 | 0.15 | 0.07 | 0.02 | -0.14 | 0.24 | 0.38 | 0.23 | |
| Cytokines | IFN-a | 0.23 | 0.78* | 0.02 | -0.05 | 0.07 | N/A | N/A |
| IL-1RA | 0.35 | 0.27 | 0.38 | -0.38 | 0.55** | N/A | N/A | |
| IL-8 | 0.15 | -0.62 | 0.31 | -0.34 | 0.47* | N/A | N/A | |
| IL-10 | -0.11 | 0.29 | -0.16 | -0.45* | 0.07 | N/A | N/A | |
| IL-13 | 0.30 | 0.25 | 0.36 | 0.18 | 0.17 | N/A | N/A | |
| TNF-α | 0.11 | 0.72* | -0.02 | -0.20 | -0.01 | N/A | N/A | |
| Chemokines | IP10 | 0.48* | 0.62 | -0.10 | -0.13 | -0.13 | N/A | N/A |
| MIP-1α | 0.45 | 0.38 | 0.31 | 0.06 | 0.19 | N/A | N/A | |
| MIP-1β | 0.57* | 0.33 | 0.23 | 0.02 | 0.13 | N/A | N/A | |
| RANTES | 0.56* | 0.57 | 0.15 | 0.14 | 0.10 | N/A | N/A | |
| Growth factors | FGF-2 | -0.01 | 0.55 | 0.13 | 0.46* | -0.06 | N/A | N/A |
| HGF | 0.34 | 0.07 | -0.15 | -0.59** | 0.38 | N/A | N/A | |
| VEGF | 0.52* | 0.41 | 0.06 | -0.24 | 0.17 | N/A | N/A |
PGD2, prostaglandin D2; PGE2, prostaglandin E2; LTB4, leukotriene B4; LXA4, lipoxin A4; MaR1, maresin 1; ALT, alanine aminotransferase; AST, aspartate aminotransferase; INR, international normalized ratio; MELD, model for end-stage liver disease; BMI, body mass index; CRP, C-reactive protein; LPS, lipopolysaccharides; LBP, lipopolysaccharides binding protein; sCD14, soluble CD14; sCD163, soluble CD163; N/A, not analyzed due to insufficient data points. The numbers represent Spearman’s coefficients, *p < 0.05, **p < 0.01 (bolded).