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. 1980 Mar 15;186(3):993–996. doi: 10.1042/bj1860993

Tryptophan pyrrolase in haem regulation. The mechanism of the permissive effect of cortisol on the enhancement of 5-aminolaevulinate synthase activity by 2-allyl-2-isopropylacetamide in the adrenalectomized-rat liver.

C J Morgan, A A Badawy
PMCID: PMC1161739  PMID: 7396848

Abstract

The decreased ability of 2-allyl-2-isopropropylacetamide to enhance liver 5-amino-laevulinate synthase activity in the adrenalectomized rat is not associated with a marked depletion of the already low amount of tryptophan pyrrolase haem. Cortisol permits the porphyrogen markedly to enhance synthase activity by rendering it capable of causing a stronger depletion of pyrrolase haem, presumably as result of hormonal induction of pyrrolase synthesis.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Badawy A. A. Central role of tryptophan pyrrolase in haem metabolism. Biochem Soc Trans. 1979 Jun;7(3):575–583. doi: 10.1042/bst0070575. [DOI] [PubMed] [Google Scholar]
  2. Badawy A. A., Evans M. Regulation of rat liver tryptophan pyrrolase by its cofactor haem: Experiments with haematin and 5-aminolaevulinate and comparison with the substrate and hormonal mechanisms. Biochem J. 1975 Sep;150(3):511–520. doi: 10.1042/bj1500511. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Badawy A. A., Evans M. The effects of chemical porphyrogens and drugs on the activity of rat liver tryptophan pyrrolase. Biochem J. 1973 Dec;136(4):885–892. doi: 10.1042/bj1360885. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Badawy A. A., Evans M. The mechanism of inhibition of rat liver tryptophan pyrrolase activity by 4-hydroxypyrazolo(3,4-d)pyrimidine (Allopurinol). Biochem J. 1973 Jul;133(3):585–591. doi: 10.1042/bj1330585. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Badawy A. A., Morgan C. J. Tryptophan pyrrolase in haem regulation. The relationship between the depletion of rat liver tryptophan pyrrolase haem and the enhancement of 5-aminolaevulinate synthase activity by 2-allyl-2-isopropylacetamide. Biochem J. 1980 Mar 15;186(3):763–772. doi: 10.1042/bj1860763. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Badawy A. A. The functions and regulation of tryptophan pyrrolase. Life Sci. 1977 Sep 15;21(6):755–768. doi: 10.1016/0024-3205(77)90402-7. [DOI] [PubMed] [Google Scholar]
  7. Badawy A. A. Tryptophan pyrrolase, the regulatory free haem and hepatic porphyrias. Early depletion of haem by clinical and experimental exacerbators of porphyria. Biochem J. 1978 Jun 15;172(3):487–494. doi: 10.1042/bj1720487. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Bock K. W., Krauss E., Fröhling W. Regulation of -aminolevulinic acid synthetase by drugs and steroids in vivo and in isolated perfused rat liver. Eur J Biochem. 1971 Nov 11;23(2):366–371. doi: 10.1111/j.1432-1033.1971.tb01630.x. [DOI] [PubMed] [Google Scholar]
  9. Castro J. A., Greene F. E., Gigon P., Sasame H., Gillette J. R. Effect of adrenalectomy and cortisone administration on components of the liver microsomal mixed function oxygenase system of male rats which catalyzes ethylmorphine metabolism. Biochem Pharmacol. 1970 Aug;19(8):2461–2467. doi: 10.1016/0006-2952(70)90271-6. [DOI] [PubMed] [Google Scholar]
  10. De Matteis F. Loss of haem in rat liver caused by the porphyrogenic agent 2-allyl-2-isopropylacetamide. Biochem J. 1971 Oct;124(4):767–777. doi: 10.1042/bj1240767. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. De Matteis F. The effect of drugs on 5-aminolaevulinate synthetase and other enzymes in the pathway of liver haem biosynthesis. Basic Life Sci. 1975;6:185–205. doi: 10.1007/978-1-4615-8954-9_7. [DOI] [PubMed] [Google Scholar]
  12. Granick S., Sinclair P., Sassa S., Grieninger G. Effects by heme, insulin, and serum albumin on heme and protein synthesis in chick embryo liver cells cultured in a chemically defined medium, and a spectrofluorometric assay for porphyrin composition. J Biol Chem. 1975 Dec 25;250(24):9215–9225. [PubMed] [Google Scholar]
  13. Kato R. Drug metabolism under pathological and abnormal physiological states in animals and man. Xenobiotica. 1977 Jan-Feb;7(1-2):25–92. doi: 10.3109/00498257709036242. [DOI] [PubMed] [Google Scholar]
  14. Wetterberg L., Geller E., Yuwiler A. Glucose effect on tryptophan oxygenase and tyrosine aminotransferase induction after allylisopropylacetamide-induced porphyria in the rat. Biochem Pharmacol. 1970 Nov;19(11):2833–2838. doi: 10.1016/0006-2952(70)90022-5. [DOI] [PubMed] [Google Scholar]

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