Table 4.
Comparison of the overweight-years metric and BMI using Harrell's C-statistic.
| Characteristic | Harrell's C-statistic (95% CI) |
|||||
|---|---|---|---|---|---|---|
| Overweight-years | BMI | Difference in c-statistic between BMI and overweight-years | Degree of overweight | Duration of overweight | Difference in c-statistic between duration and degree of overweight | |
| Men | ||||||
| Total Cancersa | 0.598 (0.565, 0.630) | 0.598 (0.564, 0.631) | −0.001 (−0.003, 0.001) | 0.599 (0.566, 0.631) | 0.598 (0.563, 0.631) | −0.001 (−0.003, 0.001) |
| OBR-cancers | 0.612 (0.578, 0.646) | 0.611 (0.578, 0.644) | −0.001 (−0.002, 0.001) | 0.613 (0.578, 0.646) | 0.609 (0.574, 0.642) | −0.001 (−0.003, 0.001) |
| NOR-cancers | 0.599 (0.563, 0.633) | 0.589 (0.563, 0.615) | 0.001 (−0.001, 0.002) | 0.599 (0.564, 0.634) | 0.601 (0.565, 0.636) | 0.001 (−0.001, 0.002) |
| NOR-cancers excluding lung and prostate | 0.610 (0.537, 0.677) | 0.610 (0.537, 0.677) | 0.000 (−0.001, 0.001) | 0.609 (0.536, 0.678) | 0.609 (0.537, 0.677) | 0.000 (−0.001, 0.001) |
| Specific cancer sites | ||||||
| Colorectal | 0.626 (0.583, 0.668) | 0.623 (0.587, 0.657) | −0.001 (−0.002, 0.001) | 0.626 (0.585, 0.666) | 0.621 (0.585, 0.656) | −0.001 (−0.003, 0.001) |
| Pancreas | 0.606 (0.544, 0.666) | 0.606 (0.552, 0.659) | −0.001 (−0.003, 0.002) | 0.606 (0.541, 0.667) | 0.605 (0.549, 0.659) | 0.001 (−0.002, 0.004) |
| Kidney | 0.594 (0.568, 0.618) | 0.601 (0.579, 0.623) | 0.006 (0.002, 0.011) | 0.594 (0.568, 0.620) | 0.599 (0.579, 0.619) | 0.005 (−0.000, 0.009) |
| Bladder | 0.677 (0.611, 0.737) | 0.678 (0.611, 0.739) | 0.000 (−0.005, 0.006) | 0.677 (0.611, 0.737) | 0.672 (0.608, 0.731) | 0.000 (−0.005, 0.006) |
| Lung | 0.722 (0.693, 0.748) | 0.726 (0.698, 0.752) | 0.003 (0.002, 0.005) | 0.722 (0.695, 0.748) | 0.724 (0.696, 0.749) | 0.003 (0.001, 0.005) |
| Prostate | 0.597 (0.571, 0.622) | 0.596 (0.570, 0.622) | −0.000 (−0.002, 0.001) | 0.598 (0.573, 0.622) | 0.600 (0.581, 0.619) | −0.001 (−0.002, 0.000) |
| Women | ||||||
| Total Cancersa | 0.580 (0.559, 0.601) | 0.582 (0.561, 0.602) | 0.002 (−0.005, 0.008) | 0.577 (0.557, 0.596) | 0.577 (0.562, 0.592) | −0.002 (−0.008, 0.004) |
| OBR-cancers | 0.566 (0.534, 0.598) | 0.573 (0.546, 0.600) | 0.003 (−0.003, 0.009) | 0.564 (0.535, 0.593) | 0.558 (0.537, 0.579) | −0.001 (−0.006, 0.004) |
| NOR-cancers | 0.639 (0.579, 0.695) | 0.641 (0.578, 0.699) | 0.002 (−0.001, 0.005) | 0.638 (0.579, 0.693) | 0.639 (0.580, 0.695) | −0.000 (−0.002, 0.002) |
| NOR-cancers excluding lung | 0.589 (0.542, 0.634) | 0.590 (0.542, 0.635) | 0.001 (−0.002, 0.003) | 0.589 (0.542, 0.634) | 0.588 (0.542, 0.633) | −0.001 (−0.003, 0.000) |
| Specific cancer sites | ||||||
| Colorectal | 0.627 (0.584, 0.668) | 0.629 (0.590, 0.666) | −0.001 (−0.002, 0.000) | 0.628 (0.585, 0.669) | 0.629 (0.589, 0.667) | −0.000 (−0.002, 0.001) |
| Pancreas | 0.634 (0.582, 0.682) | 0.633 (0.581, 0.682) | 0.001 (−0.001, 0.003) | 0.634 (0.584, 0.682) | 0.632 (0.584, 0.678) | −0.001 (−0.004, 0.003) |
| Kidney | 0.607 (0.586, 0.627) | 0.626 (0.606, 0.645) | 0.014 (0.002, 0.026) | 0.608 (0.588, 0.628) | 0.622 (0.599, 0.644) | 0.015 (0.004, 0.025) |
| Lung | 0.743 (0.697, 0.784) | 0.743 (0.697, 0.784) | 0.002 (−0.002, 0.005) | 0.743 (0.694, 0.787) | 0.743 (0.699, 0.781) | −0.001 (−0.003, 0.002) |
| Endometrial | 0.613 (0.563, 0.661) | 0.625 (0.584, 0.663) | 0.011 (−0.001, 0.023) | 0.617 (0.572, 0.659) | 0.611 (0.566, 0.654) | −0.004 (−0.012, 0.004) |
| Ovarian | 0.583 (0.540, 0.624) | 0.582 (0.541, 0.622) | −0.001 (−0.005, 0.003) | 0.583 (0.541, 0.625) | 0.584 (0.545, 0.623) | −0.002 (−0.005, 0.001) |
| Post-menopausal breast cancer | 0.598 (0.511, 0.678) | 0.603 (0.509, 0.690) | 0.002 (−0.000, 0.005) | 0.596 (0.514, 0.672) | 0.595 (0.513, 0.672) | −0.001 (−0.003, 0.001) |
Key: Bold—significant difference in C-statistic.
All models were multivariable adjusted, including baseline age, ethnicity, alcohol, smoking, HRT.
Abbreviations: SE, standard error; OBR, obesity-related; BMI, body mass index; CI, confidence interval; MV, multivariable-adjusted.
a
The sum of OBR and NOR cancer does not equal total cancers as non-melanoma skin cancers were excluded in the EPIC cohort analyses.