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. 2024 Dec 5;7:0538. doi: 10.34133/research.0538

Fig. 2.

Fig. 2.

Circulating interleukin-6 (IL-6) mediated PM2.5-induced ovarian injury. (A) Venn plots of elevated cytokines in the circulation and ovaries of mice exposed to PM2.5. (B) Scheme of the animal study for assessing the effect of IL-6 on ovarian function. (C) The serum IL-6 levels of mice upon administration of IL-6 recombinant protein (rm IL-6) (n = 9 mice/group, 2-tailed Student t test). (D) The serum AMH level of mice treated with rm IL-6 (n = 11 mice/group, 2-tailed Student t test). (E) Ovarian H&E staining images of mice treated with rm IL-6. (F) Follicle counting results according to ovary serial sections (n = 5 mice/group, 2-tailed Student t test). (G) The proportion of regular or irregular estrous cycles of mice treated with rm IL-6 (n = 11 mice/group, chi-square test). (H to J) The serum hormone level of mice treated with rm IL-6 (n = 7 to 11 mice/group, 2-tailed Student t test). (K to M) Protein expression of hormone-synthesis-related genes in ovaries from rm IL-6-treated mice detected by Western blot (n = 3 biological replicates/group, 2-tailed Student t test). rm IL-6, IL-6 recombinant protein; KC, keratinocyte-derived chemokine.