Tabel 4.
The druglikeness studies of synthesized compounds (5a-5m) and diclofenac sodium based on Lipinski's rule of five.
| Compounds Code | Property |
Lipinski violation | |||||
|---|---|---|---|---|---|---|---|
| LogP | H-bond acceptor | H-bond donor | Polar surface area (A2) | Rotatable Bonds | Molecular weight | ||
| 5a | 4.0086 | 2 | 0 | 99.511 | 2 | 221.259 | 0 |
| 5b | 4.662 | 2 | 0 | 109.814 | 2 | 255.704 | 0 |
| 5c | 3.7142 | 3 | 1 | 104.305 | 2 | 237.258 | 0 |
| 5d | 3.7142 | 3 | 1 | 104.305 | 2 | 237.258 | 0 |
| 5e | 3.9168 | 4 | 0 | 114.164 | 3 | 266.256 | 0 |
| 5f | 4.7711 | 2 | 0 | 113.378 | 2 | 300.155 | 0 |
| 5g | 4.7711 | 2 | 0 | 113.378 | 2 | 300.155 | 0 |
| 5h | 4.7711 | 2 | 0 | 113.378 | 2 | 300.155 | 0 |
| 5i | 4.662 | 2 | 0 | 109.814 | 2 | 255.704 | 0 |
| 5j | 4.1477 | 2 | 0 | 103.676 | 2 | 239.249 | 0 |
| 5k | 4.0172 | 3 | 0 | 110.989 | 3 | 251.285 | 0 |
| 5l | 4.0172 | 3 | 0 | 110.989 | 3 | 251.285 | 0 |
| 5m | 4.0172 | 3 | 0 | 110.989 | 3 | 251.285 | 0 |
| Diclofenac Sodium | 3.9062 | 3 | 1 | 144.912 | 4 | 318.13 | 0 |