Fig. 4.

(A) A heatmap depicting differentially expressed proteins resulting from the label-free proteomics analysis of treatment groups. The clustering was generated using the average-linkage method along with Euclidean distance, utilizing the Heatmapper online tool (http://www.heatmapper.ca/expression/). (B) Venn diagram of biological process and cellular localization of the differentially up- and down-regulated proteins. (C) Venn diagram of up- and down-regulated proteins and their biological process. Analysis of the down/up-regulated mitochondria-associated proteins (D), ER-Golgi-associated proteins (E), angiogenesis-associated proteins (F), and cell differentiation-associated proteins (G) interactions created using the STRING analysis tool. GTP: Guanosine-5′-triphosphate.