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The biocompatibility of LHNTMZ, LHNrutin and LHNTMZ+rutin. (A) H&E staining of the cerebellum after LHNTMZ, LHNrutin and LHNTMZ+rutin application. The peripheral blood serum (B) AST, (C) ALT, (D) BUN and (E) CRE. (F) Analysis of IFN-γ and IL-4 levels at splenic cells by ELISPOT assays. Spot numbers were normalized according to the background seen in PBS. The experiments were performed in three biological replicates. All data are presented as mean ± SE; *P < 0.05.
