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. 2024 Nov 8;27(12):111344. doi: 10.1016/j.isci.2024.111344

Figure 3.

Figure 3

Effect of lipoprotein sub-fractions and lipid-lowering drug according to CFH rs1061170 genotype

(A) Estimates corresponding to the interactions between 49 low-density lipoprotein and high-density lipoprotein (HDL) sub-fractions and CFH genetic variant (rs1061170) on AMD. The gray dotted and red dashed lines corresponded to 5% significance threshold before and after FDR correction, respectively. The two HDL sub-fractions with FDR corrected p values < 5% (above the red dashed line) were considered for the analyses (B), (C), and (D).

(B) Effect of lipid-lowering drug on triglycerides sub-fractions in large and very large HDL according to rs1061170 genetic variant.

(C) Effects of triglycerides in large HDL (L_HDL_TG) on AMD according to rs1061170 genetic variant. The shaded areas around the solid and dotted lines corresponded to the 95% confidence intervals.

(D) Effects of triglycerides in very large HDL (XL_HDL_TG) on AMD according to rs1061170 genetic variant. The shaded areas around the solid and dotted lines corresponded to the 95% confidence intervals.