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. 2024 Dec 5;14(52):38403–38415. doi: 10.1039/d4ra06694d

IC50 values of compounds 8f, 8g, 8h, 8j, and 8l against EGFR and BRAFV600E against MCF-7 cancer cell line.

Compound EGFR inhibition IC50 ± SEM (nM) BRAFV600E inhibition IC50 ± SEM (nM)
8f 89 ± 5 69 ± 5
8g 68 ± 4 47 ± 3
8h 74 ± 5 55 ± 5
8j 78 ± 5 61 ± 5
8l 83 ± 5 64 ± 5
Erlotinib 80 ± 5 60 ± 5
Vemurafenib ND 30 ± 3