IC50 values of compounds 8f, 8g, 8h, 8j, and 8l against EGFR and BRAFV600E against MCF-7 cancer cell line.
| Compound | EGFR inhibition IC50 ± SEM (nM) | BRAFV600E inhibition IC50 ± SEM (nM) |
|---|---|---|
| 8f | 89 ± 5 | 69 ± 5 |
| 8g | 68 ± 4 | 47 ± 3 |
| 8h | 74 ± 5 | 55 ± 5 |
| 8j | 78 ± 5 | 61 ± 5 |
| 8l | 83 ± 5 | 64 ± 5 |
| Erlotinib | 80 ± 5 | 60 ± 5 |
| Vemurafenib | ND | 30 ± 3 |