Extended Data Fig. 8. Details of the interaction between Swc2 and the nucleosome in the SWR1–nucleosome in configuration I.

a, Linearized cartoon of the Swc2 subunit, the built-in coordinates are represented in yellow. The Htz1–H2B binding domain (residues 1–89) and the DNA-binding domain (residues 136–345) are highlighted. b, The residues of Swc2 that binds the DNA or interact with the H2A–H2B histones are highlighted The interaction between Swc2 and the nucleosome in the SWR1–nucleosome complex in configuration I. For simplicity, only the built in coordinates of Swc2 and the nucleosome is shown. c, Representative density for Swc2 at contact 1 (contoured at 2σ) in the SWR1–nucleosome in configuration I complex. d, Representative density for Swc2 at contact 2 (contoured at 2.5σ) in the SWR1–nucleosome in configuration I complex. The side chains of Swc2 that interacts with nucleosomal DNA is shown. e, Representative density for Swc2 at contact #3 (contoured at 5.5σ). in the SWR1–nucleosome in configuration I complex. The side chains of Swc2 that interacts with the nucleosomal DNA is shown. f, Representative density for Swc2 at contact #4 (contoured at 3σ). in the SWR1–nucleosome in configuration I complex. The side chains of Swc2 that interacts with the bottom gyre nucleosomal DNA is shown.