Extended Data Fig. 9. Residues that interact with the nucleosome are conserved between Swc2-like proteins, and additional 2D classes of SWR1-mediated nucleosome flipping.

a, The interaction between Swc2 and the nucleosome in the SWR1–nucleosome complex in configuration I. For simplicity, only the built-in coordinates of Swc2 and the nucleosome are shown. The four different contacts between Swc2 and the nucleosome are highlighted. An alignment of 116 Swc2-like proteins across various species was used to generate a sequence logo to display sequence conservation. The residues of Swc2 that bind the DNA or interact with the H2A–H2B histones are highlighted. b, Five additional intermediates of SWR1-mediated nucleosome flipping are visible after 2D classification.