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. 2024 Nov 13;636(8041):172–181. doi: 10.1038/s41586-024-08163-9

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© The Author(s) 2024, corrected publication 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 11 — a. UMAP plot showing color-coded merged cell clusters of FACS-sorted cKit⁺ HSPCs and hematopoietic lineage-depleted bone marrow cells. Hematopoietic stem cell (HSC), multi-potent progenitor (MPP), myeloid progenitor (MyPro), lymphoid progenitor (LyPro), megakaryocyte-erythrocyte progenitor (MEP), pre-B-cell (Pre-B), sinusoidal endothelial cell (sEC), arterial endothelial cell (aEC), bone marrow mesenchymal stromal cell (bmMSC), metaphyseal mesenchymal stromal cell (mpMSC), smooth muscle cell (SMC), osteoblast (Ob). b. Heat map showing top cell marker genes of each cell population shown in (a). c. Group-selected color-coded cell clusters from young or old, skull or femur as indicated. d. Frequency plots of color-coded HSPCs (top) and endothelial cells (bottom) from young skull (YS), old skull (OS), young femur (YF), old femur (OF).