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. 2024 Oct 30;636(8041):241–250. doi: 10.1038/s41586-024-08137-x

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Extended Data Fig. 4 — a,b, Differentially expressed genes (a) and differentially accessible peaks (b) between the indicated iPS-HSPC groups. c, Significantly enriched (GSEA) AML gene sets. NES: Normalized enrichment score. d, Cumulative enrichment scores for a GMP-like signature derived from human primary AML¹⁴. e, Cell-type-specific regulatory elements from Corces et al. HSC: hematopoietic stem cell; MPP: multi-potent progenitor; CMP: common myeloid progenitor; GMP: granulocyte-monocyte progenitor; LMPP: lymphoid-primed multipotent progenitor; CLP: common lymphoid progenitor; MEP: megakaryocyte-erythrocyte progenitor; Mono: monocyte; Ery: erythroid cell; NK: natural killer. f, Accessibility (Reads Per Kilobase per Million mapped ATAC reads) of the regulatory elements specific to the indicated cell types (CMP/MEP, GMP, GMP/Mono and Mono) from e. The X axis shows distance from the transcriptional start site.