Extended Data Fig. 7. Unilineage or multilineage commitment.
(A) The first six panels show the percentage of multilineage clones (identified <24 months post-transplant) in BM and PB that transition into unimyeloid clones in the late phase (>24 months). The remaining six panels show the percentage of unimyeloid clones that remain committed in the late phase. Each panel compares lineage commitment across clinical programs by age at treatment: 0–2 years and 2–15 years for MLD and WAS, and 2–15 and >30 years for β-Thal. Statistical comparisons used Student’s T-test. (B-E) Box plots representing T-cell, B-cell, erythroid, and multilineage commitment during early and late hematopoietic reconstitution. Panel order and statistical analysis are consistent with (A).