Extended Data Fig. 10. Singleton clones, exhausting HSPCs, Lineage commitment in XSCID patients.
(A) HSC commitment analysis of ISs observed only at one time point (singletons), representing committed clones that exhaust after GT. Results were stratified by clinical trials and patient age, with trends shown for multilineage and mature committed lineages in BM samples, using log spline curves with a 0.75 CI. (B) HSC lineage commitment over time expressed as percentage on the recaptured clones in XSCID patients. The plot represents the scaled relative percentage of the shared IS (y-axis) over time (x-axis) for recurrent clones (IS observed in at least two time points for each patient) on the overall number of cells observed in multilineage (green line) or mature uni-lineages (erythroid in red, myeloid in yellow, B in blue, T in light blue). Lines are spline regression curves using a log curve with 0.75 CI.