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. 2024 Oct 23;636(8041):162–171. doi: 10.1038/s41586-024-08250-x

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Fig. 2 — a, Strategy for the analysis of CD34⁺ cells and lineage output: for each time point, we computed the proportion of the shared ISs retrieved for each lineage (among myeloid, erythroid, B and T cells) and CD34⁺ ISs (sharing ratio). b, Dynamics of the sharing ratio (y axis) as lineage output (with different colours) of CD34⁺ cells over time (x axis) for the three clinical trials. Spline curves with CI 0.75. c, Box plots of sharing ratio (bar indicates median, whisker 25–75 percentiles), normalized by Z-score (y axis) isolated in all patients from 24 months and averaged, in BM and PB tissues (circle or triangular dot shapes), grouping cell markers (colours) by cell lineages. Statistical tests are performed between pairs of clinical studies (Kruskal–Wallis test). The bars represent the median, the whiskers extend to 1.5 times the interquartile range (IQR) and the P value threshold is set at 0.05. d, Similar to b, CD34⁺ BM lineage output over time stratified by age groups (0–2, 2–15 and older than 30 years old).

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