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. 2024 Dec 4;15:10566. doi: 10.1038/s41467-024-54780-3

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© The Author(s) 2024

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Fig. 4 — a Clustering of flow-sorted and sequenced B cells from the peritoneal lavage at a resolution 0.3. b Proportions of the clusters of Nmur1^iCre-eGFP Id2^fl/fl vs. littermate Id2^fl/fl mice. c Annotated and color-coded B1 and B2 cells in the peritoneal lavage. d UMAP of IL5ra⁺ B cells. e UMAPs of Ighm and Ighd. f Heatmap of differentially-regulated genes including BCR genes comparing Nmur1^iCre-eGFP Id2^fl/fl and littermate Id2^fl/fl mice. g UMAPs and (h), quantification of the most important phosphatidyl-specific heavy- and corresponding light chains, Ighv11-2, Igkv14-126 and Ighv12−3, Igkv4-91 in Nmur1^iCre-eGFP Id2^fl/fl and littermate Id2^fl/fl mice. i Ighv usage in single B1 cells from 5 mice from Nmur1^iCre-eGFP Id2^fl/fl (blue) and littermate Id2^fl/fl mice (white). Ighv gene segments are ordered by their relative proximity to the D segments. Number of cells is depicted in the Figure.