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. 2024 Sep 17;31(12):1717–1729. doi: 10.1038/s41418-024-01379-2

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Volcano plots of gene expression fold-change versus P value in RNAseq of Nlrp3^tm1Flv Nlrp3^+/+ and Nlrp3^−/− BMDMs. Total number of differentially expressed (DE, adj. P < 0.05, Benjamini–Hochberg adjusted) genes, and individual DE genes, are shown in red. Left: comparison at baseline. Middle: comparison after 3 h of LPS (10 ng/ml) stimulation. Right: comparison after 24 h of LPS (10 ng/ml) stimulation. b Heatmap of log2 normalised counts of genes commonly differentially expressed (adj P < 0.05, Benjamini–Hochberg adjusted) in all three comparisons above. c Pie charts showing the number of differentially expressed (DE) genes (adj. P < 0.05) in BMDMs and GMPs between Nlrp3^tm1Flv Nlrp3^+/+ and Nlrp3^−/− mice, and whether they are located on chromosome 11 (blue) or an alternative chromosome (grey).