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. 2024 Nov 15;15:417. doi: 10.25259/SNI_734_2024

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Copyright: © 2024 Surgical Neurology International

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Figure 2: — The key imaging course of drug holiday. (a) CET1WI on MRI showed the sixth recurrence. (b) CET1WI on MRI showed the seventh recurrence with the disappearance of the sixth recurrence. (c) CET1WI on MRI showed the eighth recurrence with regression of the seventh recurrence due to restarting the combination therapy. (d and e) CET1WI on MRI showed the ninth recurrence with gradual dissipation of the eighth recurrence during drug holiday. (f) CET1WI on MRI showed the tenth recurrence with dissipation of the ninth recurrence. (g) CET1WI on MRI showed the tenth recurrence. (h) CET1WI on MRI after the salvage surgery. The yellow arrowhead indicates a recurrent tumor that acquired resistance to combination therapy with BRAF and MEK inhibitors. The blue arrowhead indicates a drug-sensitive tumor. CET1WI: Contrast-enhanced T1-weighted imaging, MRI: magnetic resonance imaging.