Table 4.
Top 25 CpGs identified as mediators of the relationship between prenatal risk and child cognitive ability using DACT followed by CMA
| CpG | Location | Gene annotation | ACME (95% CI) |
ADE (95% CI) |
Total Effect (95% CI) |
Prop Med (95% CI) |
|---|---|---|---|---|---|---|
| cg14986172 | chr19: 59097644 | -- | −0.44 (−1.01, −0.08) | −3.40 (−5.25, −1.49) | −3.85 (−5.68, −1.92) | 0.11 (0.02, 0.28) |
| cg22633096 | chr10: 64451393 | -- | −0.43 (−0.87, −0.11) | −3.33 (−5.25, −1.36) | −3.76 (−5.59, −1.90) | 0.11 (0.03, 0.28) |
| cg23674189 | chr19: 5785241 | PRR22 (TSS1500); DUS3L (Body) | −0.50 (−0.96, −0.13) | −3.24 (−5.07, −1.38) | −3.74 (−5.56, −1.84) | 0.13 (0.03, 0.33) |
| cg25679431 | chr3: 32189008 | GPD1L (Body) | −0.49 (−0.97, −0.14) | −3.33 (−5.28, −1.43) | −3.82 (−5.65, −1.88) | 0.12 (0.04, 0.30) |
| cg26236192 | chr20: 59379733 | -- | −0.61 (−1.15, −0.19) | −3.20 (−4.98, −1.38) | −3.82 (−5.65, −1.91) | 0.16 (0.06, 0.35) |
| cg26817877 | chr2: 173539621 | -- | −0.55 (−1.05, −0.17) | −3.18 (−4.99, −1.34) | −3.73 (−5.55, −1.87) | 0.15 (0.04, 0.35) |
| cg00056002 | chr16: 88933996 | PABPN1L (TSS1500) | −0.46 (−0.97, −0.11) | −3.51 (−5.43, −1.61) | −3.97 (−5.79, −2.04) | 0.11 (0.03, 0.27) |
| cg02458632 | chr2: 62678081 | -- | −0.52 (−1.01, −0.14) | −3.31 (−5.16, −1.47) | −3.83 (−5.74, −1.88) | 0.13 (0.04, 0.30) |
| cg03112480 | chr13: 25317909 | -- | −0.39 (−0.81, −0.08) | −3.37 (−5.20, −1.51) | −3.76 (−5.63, −1.87) | 0.10 (0.02, 0.26) |
| cg03409278 | chr18: 24004595 | LINC01543 (Body) | −0.69 (−1.36, −0.18) | −3.45 (−5.45, −1.40) | −4.14 (−6.09, −2.07) | 0.16 (0.04, 0.38) |
| cg03737367 | chr19: 50005045 | MIR150 (TSS1500) | −0.42 (−0.88, −0.09) | −3.32 (−5.16, −1.44) | −3.74 (−5.60, −1.83) | 0.11 (0.03, 0.28) |
| cg04996645 | chr2: 87820882 | LINC00152 (Body) | −0.51 (−1.02, −0.12) | −3.22 (−5.05, −1.31) | −3.72 (−5.59, −1.80) | 0.13 (0.03, 0.34) |
| cg06176876 | chr20: 5159289 | CDS2 (Body) | −0.56 (−1.13, −0.14) | −3.21 (−4.97, −1.37) | −3.77 (−5.60, −1.90) | 0.14 (0.04, 0.34) |
| cg08190384 | chr3: 128734868 | EFCC1 (Body) | −0.57 (−1.15, −0.15) | −3.14 (−5.01, −1.30) | −3.71 (−5.63, −1.72) | 0.15 (0.04, 0.36) |
| cg08673194 | chr17: 17302863 | -- | −0.44 (−0.86, −0.09) | −3.19 (−4.99, −1.34) | −3.62 (−5.49, −1.74) | 0.12 (0.03, 0.29) |
| cg09125754 | chr2: 130886714 | POTEF (1st Exon; 5’UTR) | −0.53 (−1.07, −0.13) | −3.23 (−5.05, −1.41) | −3.76 (−5.66, −1.83) | 0.14 (0.04, 0.33) |
| cg09166630 | chr15: 57887006 | GCOM1 (Body); MYZAP (Body) | −0.38 (−0.83, −0.07) | −3.32 (−5.14, −1.42) | −3.70 (−5.51, −1.78) | 0.10 (0.02, 0.25) |
| cg11139633 | chr19: 34282474 | -- | −0.59 (−1.12, −0.17) | −3.10 (−4.90, −1.25) | −3.69 (−5.54, −1.75) | 0.15 (0.04, 0.36) |
| cg12984408 | chr10: 47106705 | LINC00842 (Body) | −0.67 (−1.29, −0.19) | −3.05 (−4.88, −1.22) | −3.72 (−5.64, −1.73) | 0.18 (0.06, 0.39) |
| cg13319235 | chr8: 96364247 | C8orf37-AS1 (Body) | −0.46 (−0.97, −0.10) | −3.24 (−5.02, −1.40) | −3.70 (−5.56, −1.75) | 0.12 (0.03, 0.30) |
| cg15156941 | chr15: 76578733 | ETFA (Body) | −0.41 (−0.85, −0.09) | −3.55 (−5.31, −1.76) | −3.96 (−5.82, −2.05) | 0.10 (0.02, 0.24) |
| cg19789753 | chr2: 242805962 | -- | −0.49 (−0.95, −0.13) | −3.24 (−5.04, −1.39) | −3.73 (−5.60, −1.80) | 0.13 (0.03, 0.32) |
| cg23830414 | chr21: 44491247 | CBS (Body) | −0.68 (−1.30, −0.21) | −3.08 (−4.98, −1.13) | −3.76 (−5.67, −1.81) | 0.18 (0.05, 0.42) |
| cg25061914 | chr22: 37447468 | KCTD17 (TSS1500) | −0.43 (−0.88, −0.09) | −3.45 (−5.33, −1.52) | −3.88 (−5.83, −1.93) | 0.11 (0.02, 0.27) |
| cg25426208 | chr6: 27198646 | -- | −0.54 (−1.11, −0.14) | −3.19 (−5.14, −1.26) | −3.73 (−5.58, −1.77) | 0.14 (0.04, 0.35) |
Note. CpGs not annotated to a gene are intergenic. ACME = average causal mediated effect; ADE = average direct effect; CMA = causal mediation analysis; DACT = divide-aggregate-composite null test; Prop Med = proportion mediated. All mediated pathways were significant at p < .002.