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. 2024 Dec 4;15:10527. doi: 10.1038/s41467-024-54110-7

Fig. 4. Stable expression from the inactive X-chromosome.

Fig. 4

a XIST expression in double negative (ETP, T-C), double positive (DPearly, DPlate), CD4SP and CD8SP cells based on qPCR for 3 separate qPCR probes (Supplementary Table 5). XIST expression normalized to expression of GAPDH. Bars indicate mean expression and hinges standard deviation from six biological replicates for each of the six thymocyte subpopulations. b Total minor allele read count for heterozygous SNPs in all inactive (left) and immune genes (right) in F3 (1 biological replicate for each thymocyte subpopulation). n, number of inactive or immune genes expressed from Xi in each cell type. c Minor allele read count of individual inactive or immune genes on chromosome X that are expressed from the inactive X-chromosome (Xi) in F3 (n = 1 for each thymocyte subpopulation). See “methods” for immune gene definitions. a, b, c ETP, early T cell progenitors; T-C, T cell committed thymocytes; DPearly, early double positive thymocytes; DPlate, late double positive thymocytes; CD4SP, CD4 single positive thymocytes; CD8SP, CD8 single positive thymocytes. Source data are provided as a Source Data file.