Table II.
Feto-maternal outcomes of the study population
| Vaccinated pregnant women (Exposed cohort) |
Unvaccinated pregnant women (Control cohort) |
Unadjusted P value |
|||
|---|---|---|---|---|---|
| n=280 | % | n=129 | % | ||
| Adverse feto-maternal outcome (any) | 118 | 42.1 | 60 | 46.5 | 0.408 |
| Abortion | 3 | 1.1 | 1 | 0.8 | 1† |
| Outcome | n=277 | n=128 | |||
| Live birth | 273 | 98.6 | 128 | 100 | 0.313† |
| Stillbirth | 4 | 1.4 | 0 | 0 | |
| Delivery | |||||
| Term | 216 | 78 | 92 | 71.9 | 0.405 |
| Pre-term | 45 | 16.2 | 27 | 21.1 | |
| Post-term | 16 | 5.8 | 9 | 7 | |
| Mode of delivery | |||||
| NVD | 198 | 71.5 | 98 | 76.6 | 0.284 |
| LSCS | 79 | 28.5 | 30 | 23.4 | |
| Birth weight (kg); median (IQR) | 2.7 (2.5,3) | - | 2.7 (2.4,3) | - | 0.617 |
| Low birth weight | 50 | 18.4 | 32 | 25 | 0.126 |
| SGA | 0 | 0 | 3 | 2.3 | 0.031† |
| Apgar Score | |||||
| 1 min | 8 (8,8) | - | 8 (8,8) | - | 0.313 |
| 5 min | 9 (9,9) | - | 9 (9,9) | - | 0.355 |
| NICU admission | 3$ | 1.1 | 7# | 5.5 | 0.013† |
| Fever | 12 | 4.3 | 3 | 2.3 | 0.407† |
| Seizure | 2 | 0.7 | 0 | 0 | 1† |
| Shock | 2 | 0.7 | 0 | 0 | 1† |
| Rash | 11 | 4 | 3 | 2.3 | 0.562† |
| Diarrhoea | 9 | 3.2 | 1 | 0.8 | 0.181† |
| Pneumonia | 3 | 1.1 | 0 | 0 | 0.555† |
| Pathological jaundice | 12 | 4.3 | 8 | 6.3 | 0.408 |
| Feed intolerance | 1 | 0.4 | 0 | 0 | 1† |
| Respiratory distress | 1 | 0.4 | 1 | 0.8 | 0.533† |
| Congenital anomaly | 1 | 0.4 | 0 | 0 | 1† |
| Any neonatal infections | 4 | 1.4 | 0 | 0 | 0.313† |
| Neonatal mortality | 3 | 1.1 | 1 | 0.8 | 1† |
| Failure to thrive | 1 | 0.4 | 1 | 0.8 | 0.533† |
| Renal Failure | 1 | 0.4 | 0 | 0 | 1† |
†
Fishers exact test; $shock (2), pathological jaundice (2), pneumonia (1) and respiratory distress (1) (One neonate with pneumonia also had pathological jaundice and respiratory distress, one neonate with shock also had pathological jaundice); #Fever (3), respiratory distress (1), pathological jaundice (2), reason could not be ascertained (1). NVD, normal vaginal delivery; LSCS, lower segment cesarean section, SGA, small for gestational age, Apgar Score, appearance, pulse, grimace, activity and respiration; NICU, neonatal intensive care unit