Table 1.
Anthropometric and metabolic characteristics of study subjects stratified into tertiles according to myocardial MrGlu values
| Myocardial MrGlu tertile 1 Range 0.1–16.3 μmol/min/100 g (1) |
Myocardial MrGlu tertile 2 Range 16.4–26.29 μmol/min/100 g (2) |
Myocardial MrGlu tertile 3 Range 26.3–43 μmol/min/100 g (3) |
P (1 vs. 2)§ | P (1 vs. 3)§ | P (2 vs. 3)§ | |
|---|---|---|---|---|---|---|
| Sex (F/M) | 10/9 | 8/11 | 9/10 | 0.41 | 0.87 | 0.5 |
| Age (years) | 53 ± 10 | 50 ± 12 | 48 ± 11 | 0.9 | 0.08 | 0.09 |
| BMI (kg/m2) | 32.5 ± 5 | 28.1 ± 4 | 29.2 ± 4 | 0.01 | 0.02 | 0.6 |
| Waist circumference (cm) | 108 ± 12 | 98 ± 11 | 101 ± 10 | 0.5 | 0.4 | 0.7 |
| Systolic blood pressure (mmHg) | 130 ± 12 | 124 ± 16 | 115 ± 15 | 0.5 | 0.03 | 0.1 |
| Diastolic blood pressure (mmHg) | 79 ± 11 | 75 ± 11 | 75 ± 10 | 0.9 | 0.9 | 0.7 |
| Heart rate (bpm) | 78 ± 8 | 68 ± 7 | 68 ± 4 | < 0.0001 | < 0.0001 | 0.4 |
| Fasting plasma glucose (mg/dl) | 131 ± 45 | 114 ± 35 | 100 ± 27 | 0.1 | 0.054 | 0.3 |
| HbA1c (%) | 7.1 ± 1.2 | 6.5 ± 1.1 | 5.8 ± 1.1 | 0.2 | 0.01 | 0.1 |
| Total cholesterol (mg/dl) | 186 ± 37 | 196 ± 47 | 185 ± 29 | 0.2 | 0.7 | 0.3 |
| HDL cholesterol (mg/dl) | 45 ± 10 | 48 ± 8 | 49 ± 14 | 0.3 | 0.5 | 0.8 |
| LDL cholesterol (mg/dl) | 126 ± 36 | 127 ± 36 | 118 ± 28 | 0.6 | 0.9 | 0.3 |
| Triglycerides (mg/dl) | 164 ± 74 | 119 ± 64 | 115 ± 60 | 0.2 | 0.1 | 0.7 |
| Fasting insulin (mU/ml) | 18.8 ± 10 | 11.03 ± 6 | 12.2 ± 6.5 | 0.005 | 0.01 | 0.9 |
| NGT/prediabetes/T2DM (n) | 1/4/14 | 6/6/7 | 13/1/5 | 0.005 | 0.001 | 0.2 |
| Insulin-stimulated glucose disposal (mg/min × kg FFM) | 3.16 ± 1.8 | 4.8 ± 3.1 | 8.4 ± 7.7 | 0.1 | 0.02 | 0.2 |
| Fibrinogen (mg/dl) | 299 ± 65 | 280 ± 49 | 269 ± 82 | 0.4 | 0.2 | 0.9 |
| Glucose-lowering therapy (%) | ||||||
| Meftormin (%) | 70.6 | 33.3 | 26.3 | 0.02 | 0.01 | 0.8 |
| Antihypertensive therapy (%) | 58.3 | 35.3 | 16.7 | 0.4 | 0.06 | 0.1 |
| Lipid-lowering therapy (%) | 50 | 18.8 | 10.5 | 0.02 | 0.05 | 0.8 |
Data are means ± SD, unless otherwise indicated. Categorical variables were compared by χ2 test. Comparisons between the three groups were performed using a general linear model with post hoc Fisher's least significant difference correction for pairwise comparisons
BMI body mass index, NGT normal glucose tolerance, T2DM type 2 diabetes
§P values refer to results after analyses with adjustment for age