TABLE 4.
Adjusted absolute risk of collagen and neurological AESIs by index antibiotic treatment (after sIPTW)
| Collagen and neurological AESIs | Index antibiotic treatment adjusted absolute risk, % (95% CI)a |
|
|---|---|---|
| FQ (N = 386,537) |
SXT (N = 237,120) |
|
| Any collagen AESIs | 0.28 (0.26–0.30) | 0.28 (0.26–0.31) |
| Tendon rupture | 0.07 (0.06–0.08) | 0.06 (0.05–0.07) |
| Retinal detachment | 0.04 (0.04–0.05) | 0.05 (0.04–0.06) |
| Uveitis | 0.07 (0.06–0.07) | 0.07 (0.06–0.08) |
| Aortic aneurysm | 0.10 (0.09–0.11) | 0.10 (0.09–0.12) |
| Aortic dissection | 0.01 (0.00–0.01) | 0.01 (0.00–0.01) |
a
Assessed from Days 1–90. AESIs, adverse events of special interest; CI, confidence interval; CNS, central nervous system; FQ, fluoroquinolone; sIPTW, inverse probability of treatment weighting; NTF, nitrofurantoin; PNS, peripheral nervous system; SXT, trimethoprim/sulfamethoxazole.