Table 2.
Multivariate logistic regression for lipid parameters and GDM incidence
| B | OR | 95% CI | Standard Error | p-Value | |
|---|---|---|---|---|---|
| LDL | |||||
| Continuous LDL | |||||
| Model A | 0.301 | 1.351 | [1.021, 1.788] | 0.143 | 0.035 |
| Model B | 0.404 | 1.499 | [1.074, 2.091] | 0.170 | 0.017 |
| Binary LDL(cut-off 2.95mmol/L) | |||||
| Model A | 0.594 | 1.812 | [1.196, 2.745] | 0.212 | 0.005 |
| Model B | 0.710 | 2.033 | [1.255, 3.293] | 0.246 | 0.004 |
| HDL | |||||
| Continuous HDL | |||||
| Model A | -0.842 | 0.431 | [0.221, 0.839] | 0.340 | 0.013 |
| Model B | -0.991 | 0.371 | [0.168, 0.821] | 0.405 | 0.014 |
| Binary HDL(cut-off 1.32mmol/L) | |||||
| Model A | -0.593 | 0.553 | [0.355, 0.860] | 0.226 | 0.009 |
| Model B | -0.619 | 0.539 | [0.321, 0.902] | 0.263 | 0.019 |
| LDL/HDL | |||||
| Continuous LDL/HDL | |||||
| Model A | 0.487 | 1.628 | [1.244, 2.130] | 0.137 | < 0.001 |
| Model B | 0.560 | 1.750 | [1.286, 2.383] | 0.157 | < 0.001 |
| Binary LDL/HDL(cut-off 2.02) | |||||
| Model A | 0.671 | 1.957 | [1.258, 3.044] | 0.225 | 0.003 |
| Model B | 0.782 | 2.186 | [1.308, 3.656] | 0.262 | 0.003 |
| TC/HDL | |||||
| Continuous TC/HDL | |||||
| Model A | 0.373 | 1.452 | [1.164, 1.811] | 0.113 | < 0.001 |
| Model B | 0.429 | 1.536 | [1.196, 1.973] | 0.128 | < 0.001 |
| Binary TC/HDL(cut-off 3.15) | |||||
| Model A | 0.664 | 1.942 | [1.243, 3.034] | 0.228 | 0.004 |
| Model B | 0.817 | 2.264 | [1.346, 3.807] | 0.265 | 0.002 |
| TG/HDL | |||||
| Continuous TG/HDL | |||||
| Model A | 0.119 | 1.126 | [0.919, 1.381] | 0.104 | 0.253 |
| Model B | 0.148 | 1.160 | [0.927, 1.451] | 0.114 | 0.194 |
| Binary TG/HDL(cut-off 0.68) | |||||
| Model A | 0.537 | 1.710 | [1.104, 2.649] | 0.223 | 0.016 |
| Model B | 0.731 | 2.076 | [1.240, 3.475] | 0.263 | 0.005 |
p-values were calculated using multivariate logistic regression. Binary cut-offs were determined with ROC analysis. Model A: adjusted to all significant factors in Table 1 (age, BMI, pre-pregnancy fasting plasma glucose, LH, and E2); Model B: adjusted to risk factors from literature (age, BMI, pre-pregnancy fasting plasma glucose, multiparity, total testosterone, antral follicle count, anti-Müllarian hormone, and total vitamin D). Abbreviations: B = Regression coefficient; BMI = body mass index; CI = Confidence Interval for OR; GDM = gestational diabetes mellitus; HDL = high-density lipoproteins; LDL = low-density lipoproteins; LH = luteinizing hormone; OR = odds ratio; ROC = receiver operating characteristic; TC = total cholesterol; TG = triglycerides. The full tables can be found in Supplementary Tables 1–5