Table 4.
Magnetic resonence imaging measured superficial femoral artery velocities and measures of plaque burden, and clinical markers of PAD of diabetic and non-diabetic PAD patients.
| Diabetic PAD Patients |
Non-Diabetic PAD Patients |
||||
|---|---|---|---|---|---|
| N | Median (IQR) | N | Median (IQR) | P-value | |
|
| |||||
| A. MRI Parameters | |||||
|
| |||||
| SFA Velocities | |||||
|
| |||||
| Proximal SFA average velocity, cm/s | 27 | 28.0 (20.53, 44.83) | 43 | 24.75 (24.75, 34.45) | 0.08 |
| Proximal SFA maximum velocity, cm/s | 27 | 53.6 (38.73, 89.43) | 43 | 41.49 (15.9, 60.75) | 0.033 |
| Proximal SFA minimum velocity, cm/s | 27 | 4.05 (2.13, 8) | 43 | 7.29 (1.5, 9.2) | 0.50 |
| Distal SFA average velocity, cm/s | 27 | 25.85 (15.2, 51.96) | 42 | 15.89 (9.92, 24.65) | 0.021 |
| Distal SFA maximum velocity, cm/s | 27 | 40.8 (23.7, 71.90) | 42 | 27.4 (12.54, 41.67) | 0.012 |
| Distal SFA minimum velocity, cm/s | 27 | 4.92 (5.73, 7.34) | 42 | 4.33 (4.33, 7.75) | 0.53 |
| Delta minimum velocity, cm/s | 27 | −0.02 (−1.59, 1.71) | 42 | 0.159 (−1.7, 2.18) | 0.93 |
| Delta maximum velocity, cm/s | 27 | 2.81 (−5.6, 20.17) | 42 | 4.88 (1.5, 20.14) | 0.49 |
| Delta average velocity, cm/s | 27 | 1.21 (−2.14, 10.8) | 42 | 6.53 (0.56, 12.63) | 0.26 |
|
| |||||
| SFA Plaque Burden Measures | |||||
|
| |||||
| SFA wall volume, cc | 27 | 0.042 (0.030, 0.050) | 43 | 0.037 (0.030, 0.05) | 0.41 |
| SFA lumen volume, cc | 27 | 0.016 (0.008, 0.024) | 43 | 0.017 (0.009, 0.023) | 0.95 |
| SFA total volume, cc | 27 | 0.059 (0.041, 0.074) | 43 | 0.056 (0.043, 0.065) | 0.59 |
| 24Mo Δ of SFA wall volume, cc | 14 | 0.041 (0.031, 0.051) | 24 | 0.038 (0.031, 0.045) | 0.62 |
| 24Mo Δ of SFA lumen volume, cc | 14 | 0.019 (0.012, 0.032) | 24 | 0.012 (0.007, 0.025) | 0.14 |
| 24Mo Δ of SFA total volume, cc | 14 | 0.062 (0.047, 0.082) | 24 | 0.059 (0.039, 0.068) | 0.27 |
|
| |||||
| B. Clinical Markers of PAD | |||||
|
| |||||
| Ankle brachial index | 22 | 0.78 (0.64, 0.89) | 31 | 0.8 (0.66, 1.0) | 0.32 |
| Claudication onset time, (min) | 21 | 0.56 (0.3, 2.04) | 33 | 1.30 (1.13, 2.15) | 0.025 |
| Peak walking time, (min) | 22 | 3.05 (1.19, 4.16) | 33 | 2.49 (1.48, 4.02) | 0.67 |
| Initial distance walked, (miles) | 19 | 0.02 (0.0, 0.06) | 33 | 0.04 (0.03, 0.08) | 0.003 |
| Absolute distance walked, (miles) | 20 | 0.09 (0.05, 0.135) | 33 | 0.09 (0.06, 0.18) | 0.69 |
PAD: peripheral artery disease; SFA: superficial femoral artery; MRI: magnetic resonance imaging; Delta (Δ) refers to the velocity difference between the distal and proximal SFA locations. Mo: month.